Gene: [09^/IREB1] iron-responsive element, binding protein for; aconitate hydratase (aconitase);
FUN | [1] In the
structure of mRNA of ferritin (in 5'-UTL region) and transferrin receptor
(in 3'-UTL region), a special regulatory region is differentiated according
to its functional characteristics. This region is referred to as IRE
(Iron-Responsive Element); it is capable to bind reversibly (through the
oxidation/reduction of SH-groups) the cytoplasmic iron-containing
IRE-dependent protein. At this stage, the protein affects the translation
of ferritin mRNA and the stability of transferrin receptor mRNA thus
appearing to be a key element in the regulation of intracellular iron
homeostasis. [2] The reaction catalyzed: citrate = cis-aconitate + H(2)O." |
FAG | GEM:15^/IREB2. |
REF | FUN "Hentze MW, Argos P: NAR, 19, 1739-1740, 1991 LOC,CYG,MEB "Hentze MW &: NAR, 17, 6103-6108, 1989 FUN "Kaptain S &: PNAS, 88, 10109-10113, 1991 SEQ "Rouault TA &: PNAS, 87, 7958-7962, 1990 |
SWI | SWISSPROT: P21399 |
KEY | trl, hem, ion |
CLA | coding, basic |
LOC | 09 |
MIM | MIM: 147581 |
EZN | ENZYME: 4.2.1.3 |
